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Author

Giovanna E. Hernandez

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Open access Sep 2026

DksA-dependent stringent stress response drives virulence and gastrointestinal persistence of Klebsiella pneumoniae

ABSTRACT Successful gastrointestinal (GI) colonization by bacterial pathogens requires adaptation to nutrient competition and host-derived stresses in the gut, with adaptation via the bacterial stringent stress response playing a critical role. Epidemiological data suggest that the GI tract serves as a reservoir from w...

Md. Maidul Islam, Robert L. Beckman, Noah A. Nutter et al. · 0 citations
Open access Sep 2026

DksA-dependent stringent stress response drives virulence and gastrointestinal persistence of Klebsiella pneumoniae

Using a murine model, DksA is established as a central integrator of the stringent response, coordinating membrane stress resistance, virulence traits, and gastrointestinal colonization in K. pneumoniae.

Md. Maidul Islam, Robert L. Beckman, Noah A. Nutter et al. · 0 citations

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