Hemodialysis remains the predominant form of kidney replacement therapy worldwide, yet mortality, hospitalization, symptom burden, and impaired health-related quality of life remain substantial. Historically, dialysis innovation has emphasized surrogate measures such as solute clearance and biochemical targets. Althoug...
Allen R. Nissenson, Jörgen Hegbrant, Franklin W. Maddux et al.· Journal of the American Soci...· 0 citations
BACKGROUND
Online hemodiafiltration (HDF) enhances the removal of middle molecules, including large-middle molecules, through the combined action of diffusion and convection. Randomized controlled trials (RCTs) and individual participant data (IPD) meta-analyses demonstrate improved cardiovascular outcomes and, importa...
Giovanni F. M. Strippoli, Giovanni Pellegrino, Jörgen Hegbrant et al.· JN. Journal of Nephrology (M...· 0 citations
BACKGROUND
Cardiovascular disease remains the leading cause of death in patients receiving maintenance dialysis, whereas conventional thrice-weekly hemodialysis was developed primarily around small-solute clearance rather than cardiovascular protection.
AIM
This narrative review examines dialysis strategies intended...
Carmine Zoccali, Giovanni F. M. Strippoli, Francesco Locatelli et al.· Nephrology, Dialysis and Tra...· 0 citations
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