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Giulia Pagani

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Open access Aug 2026

Mapping the NFYA 3′UTR landscape identifies alternative polyadenylation as a targetable vulnerability in prostate cancer

Findings establish NFYA  3′UTR lengthening in PCa cells via CRISPR/Cas9 or ASOs diminished NF-YA protein levels and suppressed aggressive tumor traits both in vitro and in vivo, and provide proof-of-concept for gene-specific, APA-directed therapeutic strategies.

Giulia Pagani, Chiara Casirati, Cecilia Pandini et al. · 0 citations

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