Open access
Sep 2026
Directing GABAergic neuronal identity from human iPSCs through developmental patterning.
It is shown that the chromatin state of the starting population constrains the neuronal identities specified by ASCL1 and DLX2, and it is demonstrated that the recurrent p.Tyr719∗ mutation disrupts interneuron maturation and subtype-associated transcriptional programs and impairs inhibitory synaptic transmission in hum...
Rui-Qi Hu, Linda L. Boshans, Yi-Ran Tao et al.
· Stem Cell Reports · 0 citations