The reemergence of Zika virus (ZIKV) in 2015 and its association with severe neurological manifestations highlighted the urgent need for effective antiviral therapies, which, despite extensive efforts, remain unavailable. Lapachol, a 1,4-naphthoquinone compound abundant in Brazilian plant species, seems to be a promi...
Stephanie Paola Borjas Reyes, N. Cassani, João Victor Rodrigues Dutra et al.· ACS Omega· 0 citations
The COVID-19 pandemic profoundly affected global public health. Intensive efforts have led to the development of vaccines and antiviral drugs. However, the emergence of SARS-CoV-2 variants has raised concerns about resistance to therapies, making the exploration of alternative molecular pathways a promising strategy....
E. Lourenço, Marli de F. C. Emiliano, Silvana Ribeiro et al.· ACS Omega· 0 citations
Alphaviruses, including Mayaro virus (MAYV) and Chikungunya virus (CHIKV), pose a growing public health threat, with increasing reports worldwide and no licensed antiviral treatments available. This study evaluated the antiviral activity of pyridine-3-carbohydrazide (P-3-C) against MAYV (strains BeAr and TRVL) and CHIK...
N. Contreras, N. Cassani, Mikaela dos Santos Marinho et al.· Archives of Virology· 0 citations
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