Glen J. Weiss

Experimental assessment of computationally nominated small molecules targeting the YAP–TEAD interface in Hippo pathway-altered mesothelioma cell models

Aberrant activation of the Hippo–YAP/TAZ–TEAD transcriptional axis is a recurrent feature of multiple solid tumors and contributes to tumor maintenance, lineage plasticity, and therapeutic resistance. Recent medicinal chemistry has shown that TEAD proteins are druggable, but the rate at which in silico screening nomina...