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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

Glenn R. Masson

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Open access Aug 2026

FAF1 and FAF2 enhance unfolding by p97-UFD1-NPL4 complex enabling rational design of p97 activators

VCP/p97 is an AAA+ ATPase that, together with its cofactors UFD1-NPL4 (p97-UN), unfolds ubiquitylated substrates to maintain cellular homeostasis. The human p97-UN complex associates with additional cofactors, but how these cofactors modulate p97-UN activity is not fully understood. Here, we screen cofactors and identi...

Pritha Dasgupta, Ian R. Kelsall, Gaurav Anand et al. · 0 citations
Open access Sep 2026

Structural Basis for Activation of HRI by the DELE1 C-terminal domain

Haem-Regulated Inhibitor (HRI, aka EIF2AK1) is one of four stress-sensing kinases that phosphorylate eIF2α as part of the integrated stress response (ISR). HRI was first characterized as a haem-sensing kinase where it is inhibited when bound to haem. Recent studies have revealed another role for HRI in sensing mitochon...

O. Raimi, Rupam Bhattacharjee, Min Cao et al. · 0 citations
Open access Aug 2026

USP5 acts as a proteolytic switch to control SDE2 function via UBL-directed cleavage

A non-canonical proteolytic function of USP5 is revealed, uncovering a previously unrecognised regulatory axis linking deubiquitinating enzymes to protein maturation, expanding the substrate repertoire for USP5 and providing a framework for identifying protease–substrate relationships in post-translational regulation.

Liam T. Hales, Paul M. Tammiste, Adam J. Walker et al. · 1 citation

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