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Aug 2026

Discovery of Potential Fungal Dihydroorotate Dehydrogenase Inhibitors Via Structure-based Virtual Screening for Plant Disease Control.

Dihydroorotate dehydrogenase (DHODH), a key enzyme in the de novo pyrimidine biosynthesis pathway of phytopathogenic fungi, has emerged as a promising target for fungicide discovery. In this study, compound VS-24 was identified from a commercial chemical library using molecular docking-based virtual screening and bioac...

Guo-Tai Lin, Jia-Qi Wu, Jia-Yi Zhu et al. · 0 citations

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