Govind Chandra

A conserved NLR activation switch governs global transcriptional control of antibiotic biosynthesis in Streptomyces

Nucleotide-binding and oligomerization domain-like receptors (NLRs) are conserved molecular switches known for their role in immunity. A central feature in eukaryotic NLRs is a conserved sequence motif, acting as a regulatory latch whose destabilization triggers NLR activation. Here, we show that this activation switch...