Open access
Aug 2026
DDIAS shields single-stranded DNA in mitosis and promotes vertebrate brain development.
DNA double-strand breaks and unresolved DNA replication intermediates are particularly dangerous during mitosis. Paradoxically, cells inactivate canonical DNA repair mechanisms during chromosome segregation in favor of alternative pathways that depend on TOPBP1 and CIP2A, but how these pathways function is still poorly...
Kaima Tsukada, L. Lototska, A. Tsukada et al.
· Cell · 2 citations