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Grazia Aleppo

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Open access Oct 2026

Glycemic Outcomes of Twiist™ Automated Insulin Delivery System in People with Diabetes Requiring Insulin, A Large Real-World Study.

BACKGROUND Automated insulin delivery (AID) systems are recommended for individuals with diabetes requiring insulin. Real-world effectiveness may differ from outcomes reported in prospective clinical trials. The twiist™ AID system recently received regulatory clearance, and real-world glycemic outcomes have not been pr...

Viral N. Shah, Peter J. Jacobs, Grazia Aleppo et al. · 0 citations
Review Open access Sep 2026

Comparative Effectiveness of Continuous Glucose Monitoring Versus Blood Glucose Monitoring in Pregnancy With Diabetes: Systematic Review and Meta-analysis With Trial Sequential Analysis

OBJECTIVE The value of adding continuous glucose monitoring (CGM) to blood glucose monitoring (BGM) during pregnancy is unclear. PURPOSE To clarify CGM's role in pregnancy using meta-analysis, Grading of Recommendations Assessment, Development and Evaluation (GRADE) ratings, harmonized neonate size definitions, and tri...

R. Bannuru, M. Noble, Grazia Aleppo et al. · 0 citations
Open access Sep 2026

Use of Continuous Glucose Monitoring Indicators to Guide Dose Titration of Weekly Basal Insulin Efsitora Alfa in Insulin-Naive and Basal Insulin-Experienced Adults with Type 2 Diabetes: A Retrospective Analyis.

INTRODUCTION Basal insulin dose titration has historically relied on fasting self-monitoring blood glucose (SMBG) and hypoglycemic events. This retrospective analysis of the QWINT-2 and QWINT-3 Phase 3 trials aimed to evaluate the use of continuous glucose monitoring (CGM)-derived indicators for weekly insulin efsitora...

R. Bergenstal, Michael B. Davidson, David T. Ahn et al. · 0 citations
Review Aug 2026

Early Consideration of Automated Insulin Delivery in Type 2 Diabetes: A Critical Review.

Randomized and real-world studies demonstrate that AID systems significantly improve A1C and time in range while minimizing hypoglycemia, without increasing treatment complexity or patient burden, and position AID as a practical and effective strategy to overcome long-standing therapeutic inertia in type 2 diabetes.

Z. Tariq, Grazia Aleppo, Anders L. Carlson et al. · 0 citations

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