Open access
Sep 2026
Cryo-EM Structures of Infectious Low-Twist α-Synuclein Filaments in Lewy Bodies
It is established that low-twist filaments, which include over 75% of disease-associated Lewy aSyn amyloids, share a common structural core with high-twist forms and are the predominant aSyn species in samples that engage in templated infection.
Nicholas L. Yan, Mylan Mayer, Arthur A. Melo et al.
· bioRxiv · 0 citations