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Author

Gregory M. Cook

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Open access Aug 2026

Defining the role of aerobic respiration in the metabolism and bioenergetics of Enterococcus faecalis

Enterococcus faecalis is an opportunistic pathogen and facultative anaerobe that primarily relies on fermentative metabolism to colonize a wide range of aerobic and anaerobic environments. In the presence of exogenous heme, E. faecalis can assemble a minimal electron transport chain consisting of membrane-associated pr...

Olivia Paxie, B. Nijagal, Francesca O. Todd Rose et al. · 0 citations
Sep 2026

Design, Synthesis, and Antimicrobial Activity of Novel Cyt- bd Inhibitors Targeting Energy Compensation in Mycobacterium tuberculosis

Drug-resistant Mycobacterium tuberculosis (Mtb) poses a growing threat, necessitating new therapeutic strategies. The cytochrome bcc-aa3 oxidase (Cyt-bcc) is an attractive target, yet single-agent inhibition fails owing to compensation by the alternative cytochrome bd terminal oxidase (Cyt-bd). Herein, we describe a...

Qiao Qin, Zhuo-Heng Liu, Chen-Yi Cheung et al. · 0 citations

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