Gretchen J. Mahler

Versatile Microfluidic System for Creating Recirculating Unidirectional Flow for On-Chip Cultures of Barrier Tissues

The interaction of chemicals, nanoparticles, and circulating cells with the endothelium depends on the magnitude of the mechanical shear produced by the flow of blood. When simulating those interactions with microphysiological systems (MPSs), it is critical to reproduce those shear conditions faithfully. For example, u...