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Author

Guan-Bin Chen

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Aug 2026

Double-end blocker and split input mediated CRISPR-Cas12a system for modular single-base mutation detection with low abundance.

A crRNA-universal, sensitive and specific CRISPR-Cas12a detection platform, termed DESIC (double-end blocker and split-input mediated CRISPR-Cas12a system), for single-base mutation detection, targeting four prevalent pancreatic cancer KRAS mutations and optimized the system to achieve optimal discrimination.

Shi-Zhen Li, Yang-Wei Liao, Xiao-Xiang Wang et al. · 0 citations

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