Sep 2026
Reactivation of an inert 15-mer antimicrobial peptide by truncation-directed i, i + 7 lactam cyclization.
The parent 15-mer peptide exhibited no activity against Pseudomonas aeruginosa. Previous studies demonstrated that neither all-hydrocarbon stapling (i, i + 4 octenyl bridge) nor divinylpyrimidine exogenous linker cyclization conferred anti-P. aeruginosa activity upon this sequence. In the present study, this peptide se...
Jin-Hua Zhang, Zhi-Yi Jiang, Ming-Li Jiang et al.
· Bioorganic & Medicinal Chemi... · 0 citations