Guan-Chuan Lin

ZAK kinase at the crossroads of cellular stress: functional plasticity, human pathobiology, and precision therapeutics

Mitogen-activated protein kinase kinase 20 (MAP3K20/ZAK) has emerged as a critical biophysical sensor, uniquely poised at the intersection of environmental stress and cellular fate. Its versatile signaling is primarily orchestrated by two structurally distinct splice variants: ZAKα, which drives the ribotoxic stress re...