Author

Guan-Hua Du

2 papers indexed here

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Open access Oct 2026

Fraxetin Ameliorates Cognitive Impairment in STZ-Induced Mice: Involvement of Suppressed Microglial Hyperactivation and Improved Mitochondrial Dysfunction

Therapeutic for Alzheimer’s disease (AD) remains a pressing medical challenge in the field of neuroscience. Natural compounds with structural diversity and multi-target regulatory properties have attracted increasing attention for the treatment of complex neurodegenerative disorders. Fraxetin, previously identified thr...

Jun Zhao, Yi-Ming Bai, Chao Wang et al. · Journal of Neuroimmune Pharm... · 0 citations

Open access Sep 2026

Machine Learning-Guided Discovery of Natural BACE1 Inhibitors with Enzymatic and Cellular Validation

This research provides new technology and potential lead compound for the development of future anti-Alzheimer’s disease drug as well as demonstrates that integrating machine learning-assisted virtual screening with natural product libraries is an effective strategy for discovering novel BACE1 inhibitors.

Yi-Ming Bai, Jun Zhao, Shu-Rong Zhang et al. · ACS Omega · 0 citations