Targeting lysine acetyltransferase 6A/B in cancer: a conceptual and translational review of epigenetic regulation, immune microenvironment remodeling, and the dual-compartment hypothesis
While lysine acetyltransferase 6A (KAT6A; MOZ/MYST3) and 6B (KAT6B; MORF/MYST4) function as context-dependent oncogenic drivers—with KAT6B also displaying tissue-specific tumor-suppressive roles—their pharmacological targeting holds promise as a therapeutic avenue. This conceptual and translational review synthesizes e...