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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Guanran Ding

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Aug 2026

Metabolic Vulnerability Indices and Alzheimer's Disease Risk: A Prospective Analysis of the UK Biobank Cohort.

BACKGROUND Metabolic dysfunction is implicated in Alzheimer's disease (AD) pathogenesis. Branched-chain amino acids (BCAAs) have been prospectively linked to dementia risk, yet prospective associations of composite metabolic vulnerability indices with incident AD remain untested. OBJECTIVE To examine associations of...

Guan-Ran Ding, Yuting Liu, Yi-Xin Zhao et al. · 0 citations
Review Aug 2026

The ER stress-autophagy axis in cancer-induced muscle wasting: Unveiling the IRE1α/XBP1 pathway as a therapeutic target.

This review examines how tumor-derived signals activate IRE1α/XBP1 to upregulate both the autophagy-lysosome pathway (ALP) and ubiquitin-proteasome system (UPS); its crosstalk with inflammatory and metabolic networks; and the therapeutic potential of IRE1α inhibitors, XBP1-directed strategies, and nutritional approache...

Guan-Ran Ding, Wang Yang, Yi-Xin Zhao et al. · 0 citations

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