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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Guan-Yi Li

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Open access Aug 2026

Molecular mechanism of GTPase-activating protein-assisted hydrolysis of GTP catalyzed by Cdc42.

Integrated molecular dynamics simulations and density functional theory calculations demonstrate that GAP binding promotes hydrolysis through a combination of active-site preorganization, enhanced electrostatic interactions with phosphate, and Arg305-assisted stabilization of the Gln61 position and electrostatics.

Kechen Lu, Yihan Liu, Guan-Yi Li et al. · 0 citations
Open access Aug 2026

Identification of YL064 as a novel inhibitor of ATXN3 to suppress tumor growth and metastasis by promoting degradation of oncogenic substrates

YL064 is established as a promising ATXN3 inhibitor that targets the ubiquitin-proteasome pathway to exert anti-tumor effects, highlighting its potential as a novel therapeutic agent for ATXN3-driven cancers.

Zhenge Zhang, Wenhui Bai, Yayue Tan et al. · 0 citations

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