Although long-term exposure to fine particulate matter (PM2.5) has been linked to lung cancer incidence in never-smokers (LCINS), evidence for PM2.5 constituents remains limited. This study included 262,785 never-smokers from the China Kadoorie Biobank, among whom 2646 LCINS cases were identified. Annual average concen...
Zhi-Li Xia, Yu-Ting Han, Yuan-Lin Mou et al.· Journal of Hazardous Materia...· 0 citations
BACKGROUND
The IASLC grading system has prognostic utility and potential therapeutic implications in invasive non-mucinous lung adenocarcinoma (LUAD), but the molecular basis underlying the grading spectrum remains unclear.
METHODS
We performed whole-genome sequencing in 138 Chinese patients with invasive non-mucinou...
Lu He, Xian-Feng Xu, Ling-Feng Bi et al.· Lung Cancer· 0 citations
The findings demonstrate that functionally verified promoter variants represent a previously unrecognised determinant of mortality risk, highlighting the potential value of looking beyond coding sequences in future studies and provide clues that functional promoter variants may merit consideration when expanding action...
Congcong Chen, Jiawen Zhu, Ziye Xu et al.· Journal of Medical Genetics· 0 citations
Paternal and maternal aging exhibited distinct mutational patterns, with maternal DNM accumulation accelerating at advanced ages, and in vitro embryo manipulation was associated with increased early post-zygotic mosaic mutations, particularly C > A substitutions linked to delayed neurocognitive development at 1 year.
N. Qin, Jun-Cheng Dai, Yue Jiang et al.· Nature Medicine· 1 citation
This study demonstrates the involvement of noncoding variants in the TBX1 enhancer in TOF pathogenesis, highlighting the feasibility of using organoids to decipher the underlying mechanisms of unconserved noncoding regions in developmental malformations.
Jimiao Gao, T. Jiang, Yingyi Quan et al.· Science China Life Sciences· 0 citations
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