Stereoselective Synthesis of cis-1,3-Diaminocyclitols via a Tandem Iodocyclization/Ring-Opening Strategy.
Aminoglycoside antibiotics containing the 1,3-diaminocyclohexanetriol core, namely, 2-deoxystreptamine (2-DOS), represent a class of clinically widely used anti-infective agents with significant research importance. However, the current lack of synthetic strategies for constructing diverse aminocyclitol cores has restr...