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Guang-Jie Han

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Open access Oct 2026

MRI-Based Radiomics Predicts FAP Expression and Immunosuppressive Tumor Microenvironment in Hepatocellular Carcinoma

Purpose: To develop a Magnetic resonance imaging (MRI) -based radiomics-clinical model for noninvasive prediction of fibroblast activation protein (FAP) expression in hepatocellular carcinoma (HCC), and to explore its association with tumor microenvironment (TME) characteristics and potential immunotherapy response. Pa...

Ruo-Lian Gao, Guang-Jie Han, Qi Wang et al. · 0 citations
Open access Aug 2026

Concurrent expression of glucose-6-phosphate dehydrogenase and secreted phosphoprotein 1 characterizes an aggressive and immunosuppressive tumor state in hepatocellular carcinoma

Introduction Despite improved outcomes with combined hepatic arterial infusion chemotherapy (HAIC) and systemic therapy in hepatocellular carcinoma (HCC), therapeutic resistance is frequently driven by the tumor microenvironment. We aimed to explore biological features associated with therapeutic resistance in HCC. Met...

Guang-Jie Han, Li-Li Mi, Jian-Fei Shi et al. · 0 citations
Open access Sep 2026

Noninvasive prediction of microvascular invasion in hepatocellular carcinoma using a fusion model of 5-mm optimal peritumoral radiomics and imaging features based on multiphasic gadoxetic acid-enhanced MRI

Background Microvascular invasion (MVI) is a remarkable factor used to predict postoperative recurrence and decide the management plan in patients with hepatocellular carcinoma (HCC). In this study, using a multiscale approach (5-, 10-, 15-mm), we investigated the biological optimal scale of radiomics features for gado...

Yan-Li Zheng, Li-Li Mi, Guang-Jie Han et al. · 1 citation

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