Author

Guang-Lin Liu

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Open access Oct 2026

Route-Dependent Behavioral, Dopaminergic, and Transcriptomic Adaptations to Nicotine Aerosol Inhalation and Systemic Injection in Male Mice.

Nicotine is one of the most widely used psychoactive substances, yet most preclinical studies rely on subcutaneous injection, which does not fully model inhalation-based exposure. How different nicotine delivery paradigms shape neurobehavioral adaptations remains unclear. Here, we compared subcutaneous nicotine injecti...

Yu-Nu Ma, Zheng Song, Yi-Bo Chen et al. · Neuropharmacology · 0 citations

Open access Sep 2026

Gut microbiota remodeling contributes to nicotine-associated behavioral improvement and restoration of serotonin-related metabolism in CUMS mice

Major depressive disorder is a heterogeneous neuropsychiatric disorder in which serotonin-related pathways remain important pharmacological targets. Nicotine has been reported to exert antidepressant-like effects, yet whether the gut microbiota contributes to these effects remains unclear. Here, we found that susta...

Xia Gao, Lei Fan, Guang-Lin Liu et al. · npj Biofilms and Microbiomes · 0 citations

Open access Sep 2026

Adult-onset hippocampal α7 nicotinic acetylcholine receptor loss rapidly drives Alzheimer-like neuropathology in mice

Introduction The reduction of α7 nicotinic acetylcholine receptor (nAChR) in the hippocampus con-stitutes one of the neuropathological features observed in the brains of individuals with Alzheimer’s disease (AD), and α7 nAChR is crucial to cognitive process. However, studies involving α7 nAChR knockout mice have not de...

Jun Li, Guang-Lin Liu, Xiao-Tong Wang et al. · Frontiers in Pharmacology · 0 citations