Guang-Mang Liu

CD38-activated macrophages drive age-related placental senescence by depleting NAD+ in decidual stromal cells

As delayed childbearing becomes increasingly common, elucidating the mechanisms of age-related placental senescence is critical for the development of effective therapeutic strategies. Here, we integrate metabolomics, single-cell RNA sequencing, and spatial transcriptomics to uncover conserved features of aged placenta...