Guangqiang Wang

Ligilactobacillus salivarius AR809 and its exopolysaccharides mitigate antibiotic-induced gut dysbiosis and restore intestinal barrier function

Gut microbiota dysbiosis is closely associated with intestinal barrier dysfunction and immune imbalance. This study evaluated the efficacy of Ligilactobacillus salivarius AR809 and its exopolysaccharides (EPS809) in alleviating dysbiosis-associated intestinal dysfunction. In an antibiotic-induced murine model, both...

Faecalibacterium prausnitzii: Mechanistic Insights and Therapeutic Potential in Host-Microbe Crosstalk.

Phenolics from Phyllanthus emblica Linn. ameliorate glucose homeostasis and insulin resistance in high-fat diet/streptozotocin-induced type 2 diabetic mice.

Phyllanthus emblica Linn. contains abundant free phenolic (PEFP) and bound phenolic (PEBP), both of which have demonstrated potential antidiabetic activities. However, their comparative hypoglycemic effects and underlying mechanisms remain unclear. This study investigated the effects of PEFP and PEBP using insulin-resi...

Dietary Polysaccharides Modulate Interactions between Bacteroides and the Gut Microbiota: Gene-Level Mechanisms and Perspectives on Genome-Scale Metabolic Modeling for Community Simulation.

Bacteroides is a major gut genus involved in polysaccharide uptake and degradation, yet the gene-level mechanisms by which dietary polysaccharides modulate interactions between Bacteroides and other gut microbes remain insufficiently integrated. This review summarizes dietary-polysaccharide-driven Bacteroides interacti...

Functional role of the diadenylate cyclase gene cdaA in stress responses of the dairy starter Streptococcus thermophilus.

Results showed that cdaA is critical for osmotic and ethanol tolerance but negatively modulates bile salt resistance in S. thermophilus, suggesting that absence of cdaA confers a survival advantage under bile salt stress.