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Guang-Quan Li

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Open access Jul 2026

Host OTUB2 and viral PLpro stabilize NSP8 to promote SARS-CoV-2 replication

It is demonstrated that the host deubiquitinase OTUB2 stabilizes the viral replication factor NSP8 of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through a dual-track mechanism and identifies OTUB2 as a potential target for host-directed antiviral intervention.

Wenying Gao, Hongfei Wang, Jingguo Xin et al. · 0 citations

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