A scRNA-seq-guided gelsolin-functionalized gelatin methacryloyl platform integrating structural support and immunomodulation for osteoarthritis repair.
Osteoarthritis (OA) is a debilitating degenerative joint disease characterized by the irreversible breakdown of articular cartilage and chronic synovial inflammation. Current clinical interventions are primarily palliative, failing to address the dual challenges of structural degradation and the hostile, inflammatory m...