Author

Guangyu Lin

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Sep 2026

Semi-rational design of an (S)-selective ω-transaminase for the asymmetric synthesis of the bulky aryl-alkyl chiral amine (S)-3-methyl-1-phenylbutylamine.

ω-Transaminases (ω-TAs) provide an efficient route to the asymmetric synthesis of chiral amines. However, the intrinsic steric constraints of native ω-TA active sites lead to extremely low or undetectable catalytic activity toward bulky aryl-alkyl substrates. Here, we combined a substrate-truncation strategy with semi-...

Meng Xu, Lin Yang, Guang-Yu Lin et al. · Bioorganic chemistry (Print) · 0 citations

Jul 2026

Active Pocket Remodeling Coupled with Substrate Tunnel Engineering of ω-Transaminase CC1012 for Efficient Synthesis of (S)-1-Boc-3-aminopiperidine.

Transaminases provide an effective approach for the asymmetric synthesis of chiral amines. However, native ω-transaminases often suffer from low catalytic efficiency and poor substrate concentration tolerance, limiting industrial applicability. Targeting the synthesis of (S)-1-Boc-3-aminopiperidine, this study engineer...

Meng Xu, Han Liu, Guangyu Lin et al. · Journal of Agricultural and... · 0 citations