Japanese encephalitis virus (JEV), a zoonotic mosquito-transmitted flavivirus, induces human encephalitis and swine reproductive diseases. No antiviral drugs or treatments exist for flavivirus infections, which cause severe symptoms. Even though some host proteins can suppress flavivirus proliferation, the virus can in...
Chen Wang, Wen-Zhen Qin, Xing-Ya Wang et al.· Veterinary Research· 0 citations
Porcine epidemic diarrhea virus (PEDV) is an important enteric pathogen that causes severe diarrhea and high mortality in suckling piglets, posing a major threat to the global swine industry. In recent years, viral vectors expressing heterologous protective antigens have emerged as a promising strategy for novel vaccin...
RHuN4-F112-Cap has potential as a bivalent live-vector vaccine candidate against PRRSV and PCV2, and vaccinated piglets showed reduced DNA loads and milder lymphoid lesions after PCV2 challenge, and reduced clinical signs, lower PRRSV RNA loads, milder pulmonary lesions, and improved survival after highly pathogenic PR...
Shuolei Gao, Jiecong Yan, Juan Wang et al.· Vaccine· 0 citations
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