Author

Guangdun Peng

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Open access Aug 2026

In vivo multimodal lineage tracing of mammalian development by DeepTrack barcoding

A comprehensive recording of cell fate transitions and underlying molecular changes remains a fundamental goal in developmental biology. Here, we present DeepTrack, a lineage tracing mouse model that integrates in situ cellular barcoding with high-throughput, single-cell multi-omics to simultaneously profile clonal fat...

Chen-Yu Guo, Jun-Yao Jiang, Xiaomin Wang et al. · bioRxiv · 0 citations

Open access Jul 2026

Single-cell lineage tracing of human neuromesoderm organoids reveals TBX6-mediated posterior mesoderm fate diversification

A CRISPR/Cas9-based single-cell lineage tracing system with paired multiomics profiling in human pluripotent stem cell-derived neuromesodermal organoids to reconstruct high-resolution lineage relationships spanning 50 days of differentiation provides a clonal-resolution lineage map of human NMP differentiation and adva...

Yuanxin Liao, Cheng Chen, Meisi Li et al. · bioRxiv · 0 citations