Open access
Aug 2026
Single-Cell RNA Sequencing Reveals T-Cell Metabolic Activation and SGPL1 as a Candidate Predictor of PD-1 Resistance in Urothelial Carcinoma
T-cell metabolic activation drives anti-PD-1 responses in UC, and CD4+ T-cell-mediated M1 polarization and tumor-intrinsic SGPL1 crucially shape therapeutic outcomes, highlighting SGPL1 as a candidate metabolic target to overcome PD-1 resistance.
Zheng Chao, Yu-Chen Mei, Hao Peng et al.
· Pharmaceuticals · 0 citations