Author

Guangxia Yu

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Open access Oct 2026

Paraquat induced depression-related neurobehavioral abnormalities in zebrafish: Linkage between hepatic SAM biosynthesis and cerebral m⁶A methylation.

Accumulating epidemiological and toxicological evidence implicates the herbicide paraquat (PQ) as an environmental risk factor for depressive neuropsychiatric disorders. In this study, we demonstrated that PQ exposure induces depression-associated neurobehavioral abnormalities in adult zebrafish. Subsequent examination...

Zhen Yu, Li-Sha Li, Chen-Hao Jin et al. · Ecotoxicology and Environmen... · 0 citations

Aug 2026

Extracellular vesicles carrying the tenascin-C protein participate in glucose metabolism in neurodegenerative injury via inhibiting the AKT/GLUT1 pathway.

It is shown that EVs released by microglia exposed to 40 μM paraquat are internalized by dopaminergic neurons, where they impair glucose metabolism and induce neurodegenerative injury through the intercellular transfer of tenascin-C (TNC).

Xu Liu, Ling-Fang Chen, Xue-Dong Zhu et al. · Chemico-Biological Interacti... · 0 citations

Open access Jul 2026

METTL1-mediated N7-methylguanosine epitranscriptomic alterations modulate mRNA stability of neurodegenerative disease-associated genes following cobalt exposure.

A pivotal role for m7G modification in environmental neurotoxicant-induced neurodegeneration is established and cobalt-related RNA regulatory paradigm is revealed that expands the understanding of heavy metal-driven epitranscriptomic dysregulation, and hence offering novel therapeutic targets.

Jianping Tang, Yanbin Ren, Jingwen Li et al. · Ecotoxicology and Environmen... · 1 citation