Open access
Aug 2026
A generalizable covalent car-t platform for solid tumors enabled by oncolytic adenovirus-delivered artificial antigens
Background Chimeric antigen receptor (CAR) T-cell therapy has shown limited efficacy against solid tumors due to antigen heterogeneity and scarcity of tumor-specific targets. Methods To address those challenges, we report a covalent CAR-T strategy that achieves programmable tumor recognition via oncolytic adenovirus-me...
Lin-Pei Guo, Hui Xie, Di Yin et al.
· Frontiers in Immunology · 0 citations