Author

Gui-Hua Zeng

2 papers indexed here

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Review Open access Sep 2026

Engram cell vulnerability in neurodegeneration: from mechanistic insights to therapeutic horizons

Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD) share progressive memory impairment, yet their upstream pathologies differ. This review synthesizes evidence across these disorders to frame memory decline through engram ensembles and proposes an excita...

Qing-Yu Bai, Yan Yan, Chao-Wen Zeng et al. · Frontiers in Aging Neuroscie... · 0 citations

Open access Sep 2026

Discovery of CDK8/19 inhibitors as lead compounds for IL-6–dependent lymphoma enabled by the formal synthesis of cortistatin A

A formal synthesis of cortistatin A, a marine-derived steroidal alkaloid with potent anti-angiogenic and antileukemic activities, was achieved via a unique synthetic strategy that leveraged a late-stage SmI2-mediated oxa-bridge translocation. The de novo–synthesized simplified analog CA411 was evaluated across 38 cell...

Wen-Jun Wang, Nan Zhang, Bai-Cheng Chen et al. · Science Advances · 0 citations