Gui-Juan Cheng

Reaction Pathway and Axial Ligand Effects of C(sp3)–H Primary Amination by Unprotected Iron-Porphyrin-Nitrenoid

Engineered hemoprotein-catalyzed unprotected nitrenoid C(sp3)–H insertion has emerged as a highly promising method for the efficient synthesis of aliphatic primary amines. Despite its potential, the reaction mechanism, particularly the formation and the nature of nitrenoid species and the effects of axial ligands, stil...