Open access
Sep 2026
Modulation of intracellular transport pathways to enhance the transcytosis of nanodrugs across the blood-brain barrier
Effective treatment of brain diseases is limited by poor blood-brain barrier (BBB) penetration of drugs and their nanosized carriers. The intracellular transport of nanocarriers in brain microvessel endothelial cells (BMECs) significantly affects BBB-crossing efficiency. Most nanocarriers follow the lysosomal degra...
Li Zhang, He-Mei Cheng, Nian Wang et al.
· Nano Reseach · 0 citations