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Gui-Xian Wu

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Open access Oct 2026

Formononetin relieves chronic stress-related neointimal hyperplasia in mice by regulating HDAC6

Chronic stress severely impairs physical and mental health and is a critical risk factor for cardiovascular diseases. Formononetin (FMN) has shown promising cardiovascular protective effects, yet its functional role and molecular mechanism in chronic stress-triggered arterial neointimal hyperplasia and concomitant...

Shan-Qian Li, Wan-Hua Wu, Chao-Zhi Xu et al. · 0 citations
Open access Oct 2026

Chronic Stress Exacerbates Osteoporosis in Ovariectomized Mice With Anxiety- and Depression-Like Symptoms by Activating Cathepsin K and Impairing Autophagy.

Chronic stress (CS) acts as both an initiating and aggravating factor for depression and osteoporosis. Cumulative evidence indicates that Cathepsin K (Cat K), a cysteine protease, is functionally linked to chronic stress and exerts critical regulatory roles in bone metabolism. Nevertheless, the molecular mechanisms whe...

Shan-Qian Li, Hong-Yu Ding, Yue Huang et al. · 0 citations

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