Author

Gui-Xin Wang

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Open access Sep 2026

Keratinocyte-derived CXCL-CXCR2 ligand-receptor axis by MED1 orchestrates neutrophil phenotypes during psoriasis

Psoriasis is a chronic inflammatory skin disease characterized by aberrant keratinocyte proliferation and dysregulated immune responses. Increasing evidence suggests that reciprocal communication between tissue-resident keratinocytes and infiltrating immune cells shapes the inflammatory microenvironment and governs...

Ying-Xi Li, Jun-Kai Huang, Gui-Xin Wang et al. · Frontiers in Immunology · 0 citations

Open access Aug 2026

A programmed cell death learning signature predicts immunotherapy response and identifies AP1S1 as a regulator of immune exclusion in breast cancer.

This study establishes the PCDsig developed is a potential prognostic and predictive biomarker for breast cancer and provides the first evidence of AP1S1 as a core immunomodulatory oncogene that mediates immune exclusion.

Gui-Xin Wang, Jun Cao, Parhat Kaysar et al. · Chinese journal of cancer re... · 0 citations