Gui-Yang Zhang

A tunable brain-targeted PEGylated ginsenoside Rg1 derivative disrupts the ROS-mediated inflammasome-pyroptosis cascade to ameliorate Alzheimer's cognitive deficits.

The pathogenic cascade of oxidative stress, neuroinflammation, and pyroptosis serves as a core driving factor in the pathogenesis and progression of Alzheimer's disease (AD). Although ginsenoside Rg1 exhibits pleiotropic neuroprotective activities, its poor blood-brain barrier (BBB) permeability severely hinders its cl...