Review
Open access
Sep 2026
Metabolic regulation of tumor angiogenesis in colorectal cancer: mechanisms and therapeutic opportunities.
Colorectal cancer (CRC) progression is closely linked to abnormal vascular remodeling. Tumor vessels are structurally disorganized and poorly perfused, creating spatially heterogeneous regions of hypoxia and nutrient deprivation. These conditions reshape tumor metabolism by increasing glycolysis, glutamine utilization,...
Dong-Hao Tang, Qi-Jie Li, Costanza Tacchi et al.
· Biochimica et biophysica act... · 0 citations