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Detection of FGFR Alterations in Urothelial Carcinoma: Current Diagnostic Methodologies, Technical Considerations and Future Perspectives.
Conventional techniques, including DNA- and RNA-based next-generation sequencing, PCR-based companion diagnostic assays, fluorescence in situ hybridization, and immunohistochemistry are critically discussed together with emerging liquid biopsy strategies for longitudinal disease monitoring and resistance assessment.