Author

Guido Silvestri

2 papers indexed here

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Open access Sep 2026

BCL-2 inhibition at antiretroviral therapy initiation reduces the intact SIV reservoir in macaques.

The anti-apoptotic molecule BCL-2 favours the maintenance of the CD4+ T-cell reservoir during HIV infection. Whether inhibition of BCL-2 can lead to long-term reduction of the HIV reservoir is unclear. Here we initiated antiretroviral therapy (ART) in 24 simian immunodeficiency virus (SIV)-infected rhesus macaques at 1...

T. R. Wiche Salinas, J. Harper, C. Deleage et al. · Nature Microbiology · 0 citations

Jul 2026

Germline-targeting vaccine elicits HIV broadly neutralizing antibodies in nonhuman primates 2303354

It is demonstrated that germline-targeting vaccines can reproducibly elicit prespecified classes of bnAbs through the priming and maturation of rare precursor B cells under endogenous conditions and fundamental immunological findings are demonstrated.

S. Crotty, Jon M. Steichen, Patrick J. Madden et al. · Journal of Immunology · 0 citations