Author

Günther U. Höglinger

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Open access Sep 2026

Longitudinal Dynamics of the Blood Proteome Within the Alzheimer Spectrum in Down Syndrome

Background and Objectives Adults with Down syndrome (DS) have an increased risk of developing early Alzheimer disease. While our previous cross-sectional study investigated the blood proteome in the context of Alzheimer in DS, identifying CBLN4, CD14, C-X-C motif chemokine 17 (CXCL17), ectodysplasin A2 receptor (EDA2R)...

Olivia Wagemann, Georg S. Nuebling, K. Sandkühler et al. · Neurology · 0 citations

Open access Sep 2026

Dynamic [18F]PI-2620 recording facilitates prediction of β-amyloid positivity and simultaneous staging of tau and neurodegeneration

Patients with Alzheimer’s disease (AD) and clinically overlapping neurodegenerative diseases are classified molecularly using the A/T/N classification system. Apart from fluid biomarkers and structural MRI, A/T/N assessment incorporates β-amyloid-PET (A), tau-PET (T), and [18F]FDG-PET (N). We evaluated if dynamic featu...

Johannes S. Gnörich, J. Kusche-Palenga, Agnes Kling et al. · Molecular Neurodegeneration · 0 citations

Review Open access Aug 2026

Toward the prevention of clinically manifest Parkinson's disease.

Parkinson's disease (PD) is the fastest growing neurological disorder worldwide and is projected to affect unprecedented numbers of individuals by 2050. At the same time, PD research is undergoing a profound conceptual transformation. Advances in molecular neuropathology, genetics, biomarker science, artificial intelli...

Günther U. Höglinger, Franziska Hopfner · Journal of neural transmissi... · 0 citations