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Guo-Biao Yang

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Open access Sep 2026

Targeting SIRT2-mediated mitophagy to enhance ferroptosis: a novel mechanism of berberine action in non-small cell lung cancer.

INTRODUCTION Berberine (BBR), a natural isoquinoline alkaloid, has been shown to specifically bind to sirtuin 2 (SIRT2) and exhibit anticancer activity. This study aimed to elucidate the therapeutic mechanisms of BBR in non-small cell lung cancer (NSCLC). MATERIAL AND METHODS A murine xenograft tumor model of NSCLC w...

Ming-Liang Wu, Guo-Biao Yang, Jian-Ye Yang et al. · 0 citations

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