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Oct 2026

Discovery of new 7-azaindole derivatives as CSN5 inhibitors with in vitro antitumor activity against triple-negative breast cancer.

COP9 signalosome subunit 5 (CSN5) exerts critical deneddylase activity and is frequently overexpressed in triple-negative breast cancer (TNBC), representing a compelling antitumour target. However, to date, only a limited number of inhibitors targeting CSN5 have been reported, and none of them have advanced into clinic...

Zhi-Wen Yang, Wen-Yi Liu, Yi-Chun Miao et al. · 0 citations
Review Open access Sep 2026

EGNN ‐Based Generative Models for 3D Molecular Generation

It is argued that future drug‐oriented systems should combine joint 2D–3D graph generation, physically credible interaction modeling, synthesis and ADMET constraints, multi‐objective optimization, and closed‐loop experimental feedback.

Si-Liang Chen, Dai-Han Wang, Zhao-Ping Pan et al. · 0 citations

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