HIV-1 persistence under suppressive antiretroviral therapy (ART) remains a major barrier to eradication, yet the contribution of naturally occurring viral variation to transcriptional regulation is incompletely understood. Here, we identify an HIV-1 Tat variant (R52W) that attenuates viral transcription through the dis...
Hong-Jie Chen, Nan Jiang, Yu-Yang Tang et al.· bioRxiv· 0 citations
We have established and optimized a robust protocol to isolate, culture, and study primary human brain myeloid cells (BrMCs) from rapid-autopsy postmortem brain tissues obtained from people with or without HIV-1 (HIV), in which >97.3% of BrMCs are brain microglia (MG). Therefore, we refer to these isolated BrMCs as MG...
Nikesh Katuwal, Xiao-Yi Li, Yu-Yang Tang et al.· Journal of Visualized Experi...· 0 citations
Antiretroviral therapy (ART) effectively suppresses systemic HIV replication but does not eradicate viral reservoirs in the brain, where their identity and contribution to neurological injury remain poorly defined. Using bulk, single-cell, and single-nucleus transcriptomics of postmortem human brain tissue, we identify...
C. S. Shabangu, Hong-Jie Chen, A. Manickam et al.· bioRxiv· 0 citations
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