Author

Guo-Dong Lu

2 papers indexed here

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Open access Jul 2026

Targeting KLF4 Degradation by Doxycycline Restores Peroxisome Lipid Metabolism and Mitochondrial Energy Production in Acute Kidney Injury.

It is demonstrated that doxycycline directly binds KLF4 and promotes its ubiquitin-mediated degradation via the E3 ligase FBXO32, which restores ACOX3/IDH2-mediated fatty acid oxidation and the TCA cycle, enhancing cellular resilience against ischemic crisis.

Ji Feng, Zhiyuan Yao, Yu-Hong Li et al. · Pharmacological Research · 0 citations

Aug 2026

Medicarpin triggers Fas cell surface death receptor-mediated apoptosis by inhibiting epidermal growth factor receptor/signal transducer and activator of transcription 3 pathway and protective autophagy in liver cancer.

The findings identify medicarpin as a novel EGFR‑modulating natural compound that induces Fas-mediated apoptosis in liver cancer, independent of p53 status.

Yong-zhuo Li, Chun-Ping Huang, Jing Li et al. · Phytomedicine · 0 citations