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Guo-Dong Pang

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Open access Sep 2026

TRPV4-linked oxidative–lysosomal stress in myocardial ischemia/reperfusion: disease-matched transcriptomics and functional analysis in OGD/R cardiomyoblasts

Background Myocardial ischemia/reperfusion (MI/R) injury involves oxidative stress, lysosomal dysfunction, and altered autophagy. TRPV4 may link Ca2+ dysregulation to these processes, but its role in lysosomal membrane permeabilization (LMP) and autophagic impairment remains unclear. Methods Three disease-matched mouse...

Jie Yang, Jin-Cheng Li, Guan-Yao Li et al. · 0 citations

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